Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Oct 2010
Randomized Controlled TrialHuman papillomavirus-based cervical cancer prevention: long-term results of a randomized screening trial.
Screen-and-treat approaches to cervical cancer prevention are an attractive option for low-resource settings, but data on their long-term efficacy are lacking. We evaluated the efficacy of two screen-and-treat approaches through 36 months of follow-up in a randomized trial. ⋯ In this trial, a screen-and-treat approach using HPV DNA testing identified and treated prevalent cases of CIN2+ and appeared to reduce the number of incident cases of CIN2+ that developed more than 12 months after cryotherapy.
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J. Natl. Cancer Inst. · Sep 2010
Effects of prostate-specific antigen testing on familial prostate cancer risk estimates.
Family history is a strong risk factor for prostate cancer. The aim of this study was to investigate whether increased diagnostic activity is related to the incidence of prostate cancer among brothers of men with prostate cancer. ⋯ Increased diagnostic activity among men with a family history of prostate cancer appears to contribute to their increased risk of prostate cancer and to lead to detection bias in epidemiological and genetic studies of familial prostate cancer.
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J. Natl. Cancer Inst. · Aug 2010
Long-term survivors of childhood Ewing sarcoma: report from the childhood cancer survivor study.
The survival of Ewing sarcoma (ES) patients has improved since the 1970s but is associated with considerable future health risks. ⋯ Long-term survivors of childhood ES exhibit excess mortality and morbidity.