Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Sep 2009
Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancer.
The mitogenic and growth-stimulatory effects of insulin-like growth factors appear to play a role in prostate carcinogenesis, yet any direct association of circulating insulin levels and risk of prostate cancer remains unclear. ⋯ Elevated fasting levels of serum insulin (but not glucose) within the normal range appear to be associated with a higher risk of prostate cancer.
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J. Natl. Cancer Inst. · Sep 2009
Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries.
Few studies have evaluated the independent effect of a cancer diagnosis on vulnerability and frailty, which have been associated with adverse health outcomes in older adults. ⋯ Diagnosis of a non-skin cancer was associated with increased levels of having disability, having geriatric syndromes, and meeting criteria for vulnerability and frailty.