British journal of clinical pharmacology
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Br J Clin Pharmacol · Jan 1985
Comparative Study Clinical Trial Controlled Clinical TrialA double-blind comparison of alprazolam, diazepam and placebo in the treatment of anxious out-patients.
In a double-blind 28-day comparison of alprazolam, diazepam and placebo, alprazolam 1.5-3 mg/day was of equivalent anxiolytic effect to 15-30 mg diazepam/day and there was some evidence of antidepressant activity by alprazolam, but not diazepam, in neurotic depression. No serious side-effects or laboratory abnormalities were encountered.