British journal of clinical pharmacology
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Br J Clin Pharmacol · Nov 1986
Comparative Study Clinical Trial Controlled Clinical TrialEffect of glycopyrrolate and atropine on thermoregulation after exercise.
The effects of two anticholinergic drugs on heat production (derived from oxygen consumption), sweating and core and skin temperature were compared with saline placebo in five healthy volunteers, before and after exercise. There were no significant differences between the groups in resting and peak heat production after exercise. Sweat evaporation rate increased after exercise in all cases, but there was individual variation in response to the drugs. ⋯ Core temperature increased following exercise, but there were no significant differences between the anticholinergic drugs and saline placebo. Although clinical doses of anticholinergic drugs, when compared with saline placebo, inhibited sweating after exercise, core temperature was not significantly increased. Therefore it is suggested that non-evaporative heat loss compensated for the reduction in sweating due to anticholinergic drugs.