British journal of clinical pharmacology
-
Br J Clin Pharmacol · Aug 1989
Neuromuscular blockade with vecuronium in paediatric patients with burn injury.
1. The effect of body surface area (BSA) burn injury on neuromuscular pharmacodynamics of vecuronium was evaluated. 2. ⋯ These values were significantly higher than the value for control patients, which was 18 micrograms kg-1. 4. Burn injury induces a resistance to the neuromuscular effects of vecuronium, the magnitude of which is related to burn size.