British journal of clinical pharmacology
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Br J Clin Pharmacol · Feb 1995
Randomized Controlled Trial Clinical TrialInfluence of the behaviour pattern on the nocebo response of healthy volunteers.
The occurrence of a nocebo effect after placebo administration to healthy volunteers in a Phase I trial was analysed according to their type of personality (Bortner Rating Scale). More subjects with a behaviour pattern A (competitive and aggressive) (50%) described subjective side effects of the placebo than type B subjects (17%, P = 0.03). ⋯ The nocebo response was not statistically correlated with professional status. These results suggest that volunteer's type of personality might influence the reporting of subjective symptoms after placebo, and therefore impair the evaluation of new drugs in Phase I clinical trials.