British journal of clinical pharmacology
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Br J Clin Pharmacol · Jan 1997
Randomized Controlled Trial Clinical TrialThe effect of repeated-dose activated charcoal on the pharmacokinetics of sodium valproate in healthy volunteers.
We investigated the effects of repeated-dose charcoal administered several hours after sodium valproate on the pharmacokinetics of a single dose of the drug in healthy volunteers. ⋯ Repeated-dose activated charcoal does not appear to enhance the rate of elimination of sodium valproate after therapeutic doses of the drug and any beneficial effect of charcoal in overdose may be to prevent absorption of valproate still present in the gut.