British journal of clinical pharmacology
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Br J Clin Pharmacol · Jan 2001
Clinical TrialEffect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia.
To test the hypothesis that the alpha2-adrenergic agonist, dexmedetomidine, dilates the pupil and does not alter the pupillary light reflex of anaesthetized patients. ⋯ These pupillary effects of dexmedetomidine in humans are difficult to reconcile with the findings obtained in cats and rats that have demonstrated a direct inhibitory effect of alpha2-adrenergic agonists on the pupilloconstrictor nucleus. The increase in the magnitude of the light reflex in response to dexmedetomidine does not necessarily involve an anxiolytic mechanism.
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Br J Clin Pharmacol · Jan 2001
Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning.
To identify risk factors in the development of side-effects to N-acetylcysteine (NAC) in patients with paracetamol poisoning. ⋯ Asthma must be considered a risk factor in the development of side-effects to NAC. However, the side-effects are easily managed and there is no reason to withhold NAC from any patient with paracetamol poisoning. Paracetamol itself seems to offer some protection against the development of side-effects to NAC.