British journal of clinical pharmacology
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Br J Clin Pharmacol · Aug 2003
Randomized Controlled Trial Clinical TrialA simple pain model for the evaluation of analgesic effects of NSAIDs in healthy subjects.
Non-steroidal anti-inflammatory drugs (NSAIDs) are believed to counteract inflammation and inflammation-induced sensitization of nociceptors by inhibiting peripheral prostaglandin synthesis. We evaluated an experimental pain model for NSAIDs, that included an inflammatory component to mimic clinical inflammatory pain conditions. ⋯ The pain model we evaluated was well tolerated in all subjects and the effects of ibuprofen were highly significant. This model is simple, sensitive to NSAIDs' effects and therefore has potential for future experimental pain studies.