British journal of clinical pharmacology
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Br J Clin Pharmacol · Jun 2005
Changes in availability of paediatric medicines in Australia between 1998 and 2002.
To determine changes in the availability of medicines for children in Australia and to determine the status of newly introduced chemical entities by age category. ⋯ There have been some improvements in medicines licensing for older children, but not for children under the age of two years.
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Br J Clin Pharmacol · Jun 2005
Multicenter StudyPaediatric homoeopathy in general practice: where, when and why?
To investigate the extent of homoeopathic prescribing in primary care for childhood diseases and assess GP attitudes towards the use of homoeopathy in children. ⋯ In primary care paediatric prescribing of homoeopathic medicines most commonly occurs for self-limiting conditions in infants less than 1 year of age. Although the current level of homoeopathic prescribing is low, the widespread use in the community suggests that at least some knowledge of the main indications for homoeopathy and the preparations used would be of benefit to registered medical practitioners.
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Br J Clin Pharmacol · Jun 2005
Allometric relationships between the pharmacokinetics of propofol in rats, children and adults.
Allometric equations have proven useful for the extrapolation of animal data to determine pharmacokinetic parameters in man. It has been proposed that these equations are also applicable over the human size range including the paediatric population. The aim of this work was to study the relationship between various pharmacokinetic parameters for propofol and body weight using data from rats, children and adults. Furthermore, the utility of allometric scaling is evaluated by the prediction of propofol concentrations in humans based on data obtained in the rat. ⋯ For propofol, allometric scaling has proved to be valuable for cross species extrapolation. Furthermore, the use of the allometric equation between adults and children seems to be an adequate tool for the development of rational dosing schemes for children of varying body weights, and requires further study.