British journal of clinical pharmacology
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Br J Clin Pharmacol · Dec 2007
Randomized Controlled Trial Comparative StudyEffect of dronedarone on renal function in healthy subjects.
To assess the effects of dronedarone on renal function and tubular cation handling. ⋯ Dronedarone reduces renal creatinine and NMN clearance by about 18%, without evidence of an effect on GFR, renal plasma flow or electrolyte exchanges. This suggests a specific partial inhibition of tubular organic cation transporters (OCT). A limited increase in serum creatinine is therefore expected with dronedarone treatment, but does not mean there is a decline in renal function.
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Br J Clin Pharmacol · Dec 2007
Comparative StudyAbsence of tolerance and toxicity to high-dose continuous intravenous furosemide in haemodynamically unstable infants after cardiac surgery.
To evaluate a high-dose continuous furosemide regimen in infants after cardiac surgery. ⋯ High-dose continuous furosemide infusion for 72 h in haemodynamically unstable infants after cardiac surgery appears to be a safe and effective treatment for volume overload. Development of tolerance against the effects of furosemide and ototoxic furosemide concentrations were not observed.