British journal of clinical pharmacology
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Br J Clin Pharmacol · Mar 2007
ReviewDose-response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies.
Establishing the dose-response relationship for clinically useful doses of aspirin, ibuprofen and paracetamol has been difficult. Indirect comparison from meta-analysis is compromised by too little information at some doses. ⋯ Use of trials making direct comparison of two different doses of target drugs revealed the underlying dose-response curve for clinical analgesia.