British journal of clinical pharmacology
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Br J Clin Pharmacol · Aug 2007
Review Case ReportsCardiovascular toxicity due to venlafaxine poisoning in adults: a review of 235 consecutive cases.
Venlafaxine may increase the risk of arrhythmia in certain patients. We sought to characterize the cardiovascular effects of venlafaxine overdose in adults. ⋯ Venlafaxine overdose is associated with sympathomimetic cardiovascular effects and prolonged QTc, irrespective of coingested drugs. These mechanisms might pose an increased risk of arrhythmia and require further exploration.
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Br J Clin Pharmacol · Aug 2007
Clinical TrialAge dependent systemic exposure to inhaled salbutamol.
To determine the effect of age on systemic exposure to inhaled salbutamol in children. ⋯ For similar systemic exposure, dosing should be adjusted to age or size but not on a fixed microg kg(-1) basis, which may lead to unnecessary suboptimal dosing.