British journal of clinical pharmacology
-
Br J Clin Pharmacol · Nov 2008
Randomized Controlled Trial Comparative StudyInhibition of flucloxacillin tubular renal secretion by piperacillin.
To explore the extent, time course, site(s), mechanism and possible clinical relevance of the pharmacokinetic (PK) interaction between piperacillin and flucloxacillin. ⋯ Piperacillin inhibits renal and nonrenal elimination of flucloxacillin. This interaction seems clinically significant, as total clearance was reduced by a factor of 1.5 for the lower and 2.1 for the higher doses. PK interactions, especially with piperacillin, are likely to occur also with other beta-lactam combinations and might be useful to improve the effectiveness of antibacterial treatment.