British journal of clinical pharmacology
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Br J Clin Pharmacol · Dec 2008
Population pharmacokinetics of oral diclofenac for acute pain in children.
To develop a population pharmacokinetic model for a new diclofenac suspension (50 mg 5 ml(-1)) in adult volunteers and paediatric patients, and recommend a dose for acute pain in children. ⋯ This study has shown 1 mg kg(-1) diclofenac to produce similar exposure in children aged 1 to 12 years as 50 mg in adults, and is acceptable for clinical practice; patients are unlikely to obtain further benefit from higher doses.