British journal of clinical pharmacology
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Br J Clin Pharmacol · Jan 2009
Randomized Controlled TrialEffect of naproxen on the hypothalamic-pituitary-adrenal axis in healthy volunteers.
To study the effect of the nonsteroidal anti-inflammatory drug naproxen on the activity of the hypothalamic-pituitary-adrenal (HPA) axis in healthy volunteers. ⋯ The use of naproxen does not influence the activity of the HPA axis in healthy volunteers under basal circumstances or in response to physical stress.
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Br J Clin Pharmacol · Jan 2009
Relationship between HIV protease inhibitors and QTc interval duration in HIV-infected patients: a cross-sectional study.
QTc interval prolongation and torsades de pointes have been reported in HIV-infected patients. Protease inhibitors (PIs) are suspected to contribute to this adverse reaction. However, many factors can prolong QTc interval. We examined factors influencing QTc duration in HIV-infected patients. ⋯ Although PIs block in vitro hERG current, they are not independently associated with QTc interval prolongation. Prolonged QTc interval in HIV-infected patients is primarily associated with factors commonly known to prolong QT and with the duration of HIV infection.