Philosophical transactions of the Royal Society of London. Series B, Biological sciences
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Philos. Trans. R. Soc. Lond., B, Biol. Sci. · Aug 2020
The role of ritual behaviour in anxiety reduction: an investigation of Marathi religious practices in Mauritius.
While the occurrence of rituals in anxiogenic contexts has been long noted and supported by ethnographic, quantitative and experimental studies, the purported effects of ritual behaviour on anxiety reduction have rarely been examined. In the present study, we investigate the anxiolytic effects of religious practices among the Marathi Hindu community in Mauritius and test whether these effects are facilitated by the degree of ritualization present in these practices. Seventy-five participants first experienced anxiety induction through the public speaking paradigm and were subsequently asked to either perform their habitual ritual in a local temple (ritual condition) or sit and relax (control condition). ⋯ The degree of ritualization in the ritual condition showed suggestive albeit variable effects, and thus further investigation is needed. We conclude the paper with a discussion of various mechanisms that may facilitate the observed anxiolytic effects of ritual behaviour and should be investigated in the future. This article is part of the theme issue 'Ritual renaissance: new insights into the most human of behaviours'.
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Philos. Trans. R. Soc. Lond., B, Biol. Sci. · Aug 2020
Ritual explained: interdisciplinary answers to Tinbergen's four questions.
Convergent developments across social scientific disciplines provide evidence that rituals are a psychologically prepared and culturally inherited behavioural hallmark of our species. The dramatic diversity of ritual practices ranges from simple greetings to elaborate religious ceremonies, from the benign to life-threatening. Yet our scientific understanding of this core human trait remains limited. ⋯ These include answering ultimate questions about the (i) phylogeny and (ii) adaptive functions of ritual; and proximate questions about the (iii) mechanisms and (iv) ontogeny of ritual. The intersection of these four complementary lines of inquiry yields new avenues for theory and research into this fundamental aspect of the human condition, and in so doing, into the coevolution of cognition and culture. This article is part of the theme issue 'Ritual renaissance: new insights into the most human of behaviours'.
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Philos. Trans. R. Soc. Lond., B, Biol. Sci. · May 2019
The ethics of genome editing in non-human animals: a systematic review of reasons reported in the academic literature.
In recent years, new genome editing technologies have emerged that can edit the genome of non-human animals with progressively increasing efficiency. Despite ongoing academic debate about the ethical implications of these technologies, no comprehensive overview of this debate exists. To address this gap in the literature, we conducted a systematic review of the reasons reported in the academic literature for and against the development and use of genome editing technologies in animals. ⋯ Our findings illuminate several key considerations about the academic debate, including a low disciplinary diversity in the contributing academics, a scarcity of systematic comparisons of potential consequences of using these technologies, an underrepresentation of animal interests, and a disjunction between the public and academic debate on this topic. As such, this article can be considered a call for a broad range of academics to get increasingly involved in the discussion about genome editing, to incorporate animal interests and systematic comparisons, and to further discuss the aims and methods of public involvement. This article is part of a discussion meeting issue 'The ecology and evolution of prokaryotic CRISPR-Cas adaptive immune systems'.
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Philos. Trans. R. Soc. Lond., B, Biol. Sci. · Sep 2018
ReviewThe methodological puzzle of phenomenal consciousness.
Is phenomenal consciousness constitutively related to cognitive access? Despite being a fundamental issue for any science of consciousness, its empirical study faces a severe methodological puzzle. Recent years have seen numerous attempts to address this puzzle, either in practice, by offering evidence for a positive or negative answer, or in principle, by proposing a framework for eventual resolution. ⋯ It is argued that the methodological puzzle remains obdurately with us and that, for now, we must adopt an attitude of humility towards the phenomenal. This article is part of the theme issue 'Perceptual consciousness and cognitive access'.
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Philos. Trans. R. Soc. Lond., B, Biol. Sci. · Jul 2018
ReviewThree-dimensional cell culture: from evolution to revolution.
Recent advances in the isolation of tissue-resident adult stem cells and the identification of inductive factors that efficiently direct differentiation of human pluripotent stem cells along specific lineages have facilitated the development of high-fidelity modelling of several tissues in vitro Many of the novel approaches have employed self-organizing three-dimensional (3D) culturing of organoids, which offer several advantages over conventional two-dimensional platforms. Organoid technologies hold great promise for modelling diseases and predicting the outcome of drug responses in vitro Here, we outline the historical background and some of the recent advances in the field of three-dimensional organoids. We also highlight some of the current limitations of these systems and discuss potential avenues to further benefit biological research using three-dimensional modelling technologies. This article is part of the theme issue 'Designer human tissue: coming to a lab near you'.