Journal of clinical microbiology
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J. Clin. Microbiol. · Dec 2016
Randomized Controlled Trial Comparative StudyChlorhexidine versus Tincture of Iodine for Reduction of Blood Culture Contamination Rates: a Prospective Randomized Crossover Study.
Blood cultures (BCs) are the standard method for diagnosis of bloodstream infections (BSIs). However, the average BC contamination rate (CR) in U. S. hospitals is 2.9%, potentially resulting in unnecessary antibiotic use and excessive therapy costs. ⋯ Of 2,965 BCs obtained using CH, 327 (11.03%) were positive and 115 (3.88%) were contaminated. The rates of contaminated BCs were not statistically significant between the two antiseptic agents (P = 1.0). We conclude that CH and IT are equivalent agents for blood culture skin antisepsis.
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J. Clin. Microbiol. · Aug 2011
Randomized Controlled TrialEvaluation of oral antiseptic rinsing before sputum collection to reduce contamination of mycobacterial cultures.
To assess whether rinsing with oral antiseptics before sputum collection would reduce contamination of mycobacterial cultures, 120 patients with suspected tuberculosis were randomly assigned to rinse with chlorhexidine or cetylpyridinium mouthwash before collection. The culture contamination rate was significantly lower after rinsing with chlorhexidine before collection, especially for cultures grown in MGIT medium.
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J. Clin. Microbiol. · Jun 1998
Randomized Controlled Trial Clinical TrialPositive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis.
Patients with atrophic corpus gastritis and elevated Helicobacter pylori antibody titers but 13C-urea breath test (13C-UBT) and histology results negative for H. pylori were randomized into eradication therapy or follow-up only. Antibody levels decreased significantly in six out of seven patients in the eradication group, while in the follow-up group, the titers declined in only one out of eight patients. In patients with atrophic corpus gastritis, positive serology results may indicate an ongoing infection in spite of negative 13C-UBT and histology results.