Medical hypotheses
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Cobalamin carrier proteins,the Transcobalamins (TCS), are elevated during trauma, infections and chronic inflammatory conditions. This remains un-explained. It is proposed that such TC elevations signal a need for cobalamin central to the resolution of inflammation. ⋯ Cobalamin's established regulation of EGF may additionally preserve normal function of macrophages and the coagulation cascade in wound healing. By regulating NFkappaB, Cobalamin may also be the as yet unidentified mediator needed to potentiate the anti-inflammatory action of eicosanoids derived from omega-3 essential fatty acids. Moreover, animal and human clinical data suggests that high dose cobalamin may prove a promising approach to SIRS/sepsis/septic and traumatic shock.
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Globalization is one aspect of the larger phenomenon of modernization, which describes societies characterized by progressive growth in the complexity of communications. Despite its inevitable problems, globalization is a generally desirable phenomenon, since it enables increased efficiency, effectiveness and capability of societies and thereby, potentially benefits most people most of the time. Scientific research was one of the first global communication systems, especially at its most advanced levels. ⋯ Conversely, just a few countries may provide the bulk of advanced science education teaching - as well as applied and pure research personnel - for the rest of the world: potentially China and India might supply most of world's mathematical expertise. In conclusion, there are two complementary aspects to the globalization of science education: these are standardization and specialization. We anticipate a simultaneous trend towards international convergence of basic educational structures, certificates and English usage; with increasing national differentiation of specialist educational functions.
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Brain neuronal dysfunction has been implicated in pathogenesis of migraine but direct evidence is lacking. Scintillating scotoma of migraine is generally believed to originate at the visual cortex. While cortical spreading depression is a relatively late physiological alteration in migraine, its protective role in neuronal ischaemia is increasingly being recognized. ⋯ Headache of migraine possibly arises from a similar mechanical deformation of the anterior eye segment followed by antidromic discharge in the trigeminovascular system. Lateralizing negative deficits such as homonymous hemianopia probably reflect vasospastic complications of migraine. A rational explanation for the most characteristic clinical features of migraine and a new template to elucidate the pharmacological basis of anti-migraine drugs is offered.
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We hypothesize that aerosolization of anesthetics administered intravenously to patients in the operating room may be an unintended source of exposure to physicians. This may lead to inadvertent sensitization, which is associated with an increased risk for developing addiction. This may contribute to the over-representation of certain specialties among physicians with addiction. ⋯ This report provides preliminary evidence of detection of aerosolized intravenous anesthetics using two newly developed analytical methods. We conclude that the potential exists for chronic exposure to low levels of airborne intravenously administered drugs. Further studies are under way to determine the significance of this exposure.
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Although 'hard work' and 'busyness' are somewhat similar terms, there seem to be significant differences in the way that they are used. While hard work has always been a feature of complex societies, modern society can be seen as evolving toward being dominated by jobs characterized by busyness. Busyness refers to multi-tasking - having many sequential jobs to perform and switching frequently between them on an externally-imposed schedule. ⋯ But busy jobs are hard to eliminate because they are those in which it is optimal for a variety of disparate and unpredictable tasks to be done by a single person. Consequently, those individuals who can cope with, even thrive-upon, busyness are becoming indispensable. In future 'the busy shall inherit the earth' (or, at least, the most powerful and highest paid jobs), not just in science but in all major social domains.