Medical hypotheses
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Hormone replacement therapy (HRT) is in use for more than a half of century, but the question of indications and ideal candidates for HRT remains unclear. Postmenopausal women are a population with the increasing risks for cardiovascular diseases which are the main cause of death in this group. Decline in oestrogen concentrations is linked to a number of changes in peri and postmenopause: increased total cholesterol, triglycerides, and low density lipoprotein, increased insulin resistance and impaired fibrinolysis. ⋯ We hypothesized that the early, low dosage HRT in healthy perimenopausal women would have beneficial effects on the compounds of metabolic syndrome and could decrease the risk of cardiovascular events. Beneficial effect of HRT on cardiovascular diseases is due to the maintained integrity and functional status of the endothelium in younger women. We are aware of the fact that further studies are necessary to test the effects of different doses and routes of administration of HRT on cardiovascular outcomes.
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Why is modern science less efficient than it used to be, why has revolutionary science declined, and why has science become so dishonest? One plausible explanation behind these observations comes from an essay First and second things published by CS Lewis. First Things are the goals that are given priority as the primary and ultimate aim in life. Second Things are subordinate goals or aims - which are justified in terms of the extent to which they assist in pursuing First Things. ⋯ When the senior scientists, whose role is to uphold standards, fail to posses or respond-to informed conscience, science will inevitably go rotten from the head downwards. What, then, motivates a scientist to act upon conscience? I believe it requires a fundamental conviction of the reality and importance of truth as an essential part of the basic purpose and meaning of life. Without some such bedrock moral underpinning, there is little possibility that individual scientific conscience would ever have a chance of holding-out against an insidious drift toward corruption enforced by peer consensus.
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This article is meant for, but not confined to, younger scientists who may have a series of ideas, hypotheses and projects--be they small or big--and might grapple with the objective to pursue and complete at least some, and preferably most, work in due course. And yet, the very generation, development and completion of numerous projects takes gestation periods which can be long and painful. Importantly, this simple but important truth is valid for any creative process, be it in the sciences or in the arts. ⋯ With reference to how some of Peter Doig's paintings evolve over long times and to how John Eccles and Isaac Newton worked, extended gestation periods as a key similarity of creative work by both artists and scientists are exemplified and vindicated. It is concluded that long gestation periods of creative work should be viewed as the expectation rather than the exception. Importantly, the evolutionary and somewhat intuitive commitment to several projects at the same, and often extended, periods of time can be a recipe for revolutionary results fostered by the required variation and diversity of thinking and cross-fertilization of--seemingly--unrelated themes and fields.