Journal of neurosurgery
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Journal of neurosurgery · Jun 1981
Case ReportsPharmacokinetics of epsilon-aminocaproic acid during peritoneal dialysis.
Two patients requiring peritoneal dialysis were treated with epsilon-aminocaproic acid (EACA), an antifibrinolytic agent. Samples of serum and dialysate were assayed for EACA concentrations. ⋯ Our results suggest that patients undergoing peritoneal dialysis should receive 25% of the usual recommended dose of EACA. Dialysis clearance accounted for only 58% of total body clearance, suggesting an alternative route of elimination of EACA.