Journal of endodontics
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Journal of endodontics · Dec 2012
Randomized Controlled Trial Comparative StudyAnesthetic efficacy of the inferior alveolar nerve block in red-haired women.
The exact reasons for failure of the inferior alveolar nerve (IAN) block are not completely known, but red hair could play a role. The genetic basis for red hair involves specific mutations, red hair color (RHC) alleles, in the melanocortin-1 receptor (MC1R) gene. The purpose of this prospective randomized study was to investigate a possible link between certain variant alleles of the MC1R gene or its phenotypic expression of red hair and the anesthetic efficacy of the IAN block in women. ⋯ Red hair and the MC1R gene were significantly linked to higher levels of dental anxiety but were unrelated to success rates of the IAN block in women with healthy pulps.
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Journal of endodontics · Dec 2012
Randomized Controlled Trial Comparative StudyA prospective, randomized single-blind evaluation of effect of injection speed on anesthetic efficacy of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis.
Speed of injection may affect the solution spread in the pterygomandibular space. It was hypothesized that speed of injection will affect the anesthetic efficacy of inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis. ⋯ Rate of injection has no effect on anesthetic success of IANB, but slow injections were more comfortable than rapid injections.
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Journal of endodontics · Dec 2012
Lipopolysaccharide induces the migration of human dental pulp cells by up-regulating miR-146a.
MicroRNAs are small noncoding RNAs that play crucial roles in regulating normal and pathologic functions. Bacterial lipopolysaccharide (LPS) is one of the key regulators of pulpal pathogenesis. This study investigated how LPS regulates microRNA expression and affects the phenotype of human dental pulp cells (DPCs). ⋯ The results suggested that LPS is able to increase the migration of DPCs by modulating the miR-146a-TRAF6/IRAK1 regulatory cascade.