British dental journal
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British dental journal · Sep 2001
Randomized Controlled Trial Multicenter Study Clinical TrialPain control with paracetamol from a sustained release formulation and a standard release formulation after third molar surgery: a randomised controlled trial.
To compare the analgesic efficacy and safety of a sustained release (SR) paracetamol formulation (Panadol Extend) with a standard immediate release (IR) formulation (Panadol) after third molar surgery. ⋯ SR paracetamol and IR paracetamol are clinically and statistically equivalent. While SR paracetamol and IR paracetamol were similar in terms of both onset of analgesia and peak analgesic effect, SR paracetamol had a longer duration of activity than IR paracetamol. The safety profiles of SR paracetamol and IR paracetamol were found to be very similar.