Drug and alcohol dependence
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Drug Alcohol Depend · Dec 2006
Randomized Controlled TrialRandomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence.
To conduct a 16-week, randomized, placebo-controlled, double-blind trial of two GABAergic medications, baclofen (20 mg tid) and gabapentin (800 mg tid), for the treatment of methamphetamine dependence. ⋯ While gabapentin does not appear to be effective in treating methamphetamine dependence, baclofen may have a small treatment effect relative to placebo. Future studies evaluating the effectiveness of baclofen and other GABAergic agents for treatment of methamphetamine may be warranted.