Drug and alcohol dependence
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Drug Alcohol Depend · Mar 2006
ReviewIllicit drug use and injuries: A review of emergency room studies.
The reviewed emergency room studies (n = 11) show overall prevalence rates of illicit drug use of 35-40% in studies using blood and urine toxicology and 1-5% in self-report studies. Cannabis and cocaine are the substances most prevalent in these studies, with a higher prevalence of cocaine in emergency rooms in the USA than in other countries where cannabis is the most common substance. Illicit drugs and alcohol are often used in combination. ⋯ However, illicit drug use seems to be more common in men aged 20-40 years and is strongly associated with violence-related injuries. Variations in the prevalence rates and patient characteristics can partly be explained by locale and/or country of research. Moreover, because methodological differences influence the study outcomes, methodological aspects of emergency room studies should be taken into consideration when interpreting the results.
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Drug Alcohol Depend · Mar 2006
Randomized Controlled TrialPharmacokinetics, bioavailability and opioid effects of liquid versus tablet buprenorphine.
Two tablet formulations of buprenorphine (a buprenorphine mono-product, Subutex, and a buprenorphine/naloxone combination product, Suboxone) are available for use in the treatment of opioid addiction; however, the bulk of the clinical studies supporting its approval by the US Food and Drug Administration (FDA) were conducted with a sublingual liquid preparation. To assist the clinician in interpreting the relevant literature in establishing dosing parameters for prescription of tablet buprenorphine, this study was designed to compare the steady state: (1) pharmacokinetics and bioavailability, and (2) physiological, subjective and objective opiate effects of two 8 mg buprenorphine tablets (16 mg) to those of 1 ml (8 mg/ml) buprenorphine solution based upon early reports suggesting that the bioavailability of the tablet was approximately 50% of that of the liquid. ⋯ The serum concentration achieved by 16 mg of tablet buprenorphine is higher than that of the 8 mg solution, although differences between physiologic, subjective and objective opioid effects were not noted. The relative bioavailability of tablet versus solution is estimated to be 0.71; thus, with respect to dosing parameters for the tablet, clinicians should consider using less than 16 mg to achieve bioequivalence to the 8 mg solution.