The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Nov 2007
Characterization of Pseudomonas aeruginosa isolated from clinical and environmental samples in Minia, Egypt: prevalence, antibiogram and resistance mechanisms.
To assess the prevalence, levels of antimicrobial susceptibility and resistance mechanisms of Pseudomonas. ⋯ This study examined the prevalence of P. aeruginosa, and its susceptibility patterns to different antibiotics. The presence of antibiotic-resistant P. aeruginosa isolates could be attributed to beta-lactamase production and the use of multiple drug resistance efflux pumps.
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J. Antimicrob. Chemother. · Nov 2007
Pharmacokinetics of voriconazole during continuous venovenous haemodiafiltration.
Voriconazole is a new triazole antifungal agent that is frequently used in intensive care patients with severe fungal infections. Continuous venovenous haemodiafiltration (CVVHDF) is an important extracorporal renal replacement therapy in critically ill patients suffering from severe infections and multiple organ failure. This study investigates the pharmacokinetics of voriconazole in anuric patients undergoing CVVHDF. ⋯ Voriconazole should be given without a dosage adaptation in critically ill patients without liver cirrhosis undergoing CVVHDF. However, according to results in one patient, reduction of the maintenance dosing regimen of voriconazole seems to be meaningful in patients with liver cirrhosis.
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J. Antimicrob. Chemother. · Nov 2007
Propionibacterium acnes: an under-appreciated cause of post-neurosurgical infection.
Propionibacterium acnes is increasingly recognized as a cause of post-neurosurgical infection. This review of patients with P. acnes neurosurgical infection was carried out in order to determine clinical characteristics and outcomes in relation to duration of antimicrobial treatment. ⋯ P. acnes neurosurgical infection often presents in an indolent fashion. Gram-positive bacilli on Gram stain should not be discounted as a contaminant in neurosurgical specimens. Associated bone flaps should be removed. Intravenous benzyl penicillin +/- oral penicillin VK remains effective treatment.