The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Feb 2008
Multicenter Study Comparative StudyColistin and rifampicin in the treatment of multidrug-resistant Acinetobacter baumannii infections.
The increased incidence of nosocomial infections by multidrug-resistant organisms has motivated the re-introduction of colistin in combination with other antimicrobials in the treatment of infections. We describe the clinical and microbiological outcomes of patients infected with multidrug-resistant Acinetobacter baumannii who were treated with a combination of colistin and rifampicin. ⋯ Colistin and rifampicin appears to be an effective and safe combination therapy for severe infections due to multidrug-resistant A. baumannii.
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J. Antimicrob. Chemother. · Feb 2008
Comparative StudyMortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study.
To determine the attributable mortality and excess length of stay (LOS) associated with the use of inadequate empirical antimicrobial therapy in patients with sepsis at admission to the intensive care unit (ICU). ⋯ Inadequate antimicrobial therapy at admission to the ICU with sepsis is associated with excess mortality and increases LOS.
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J. Antimicrob. Chemother. · Feb 2008
Comparative StudyFalse-positive Aspergillus galactomannan antigenaemia after haematopoietic stem cell transplantation.
Although Aspergillus galactomannan (GM) antigen detection is widely applied in the diagnosis of invasive aspergillosis (IA), false-positive reactions with fungus-derived antibiotics, other fungal genera or the passage of dietary GM through injured mucosa are a matter of concern. The aim of this study was to investigate the cumulative incidence and risk factors for false-positive GM antigenaemia. ⋯ GM antigen results must be considered cautiously in conjunction with other diagnostic procedures including computed tomography scans, especially during the first 100 days after HSCT and in patients with gastrointestinal chronic GVHD.