The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Jun 2010
An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities.
The targeted disruption of biofilms in chronic wounds is an important treatment strategy and the subject of intense research. In the present study, an in vitro model of chronic wound biofilms was developed to assess the efficacy of antimicrobial treatments for use in the wound environment. ⋯ This wound model emphasizes the potential role of the biofilm phenotype in the observed resistance to antibiotic therapies that may occur in chronic wounds in vivo.