The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Apr 2013
Outcome of inadequate empirical antibiotic therapy in emergency department patients with community-onset bloodstream infections.
Studies on the effect of inadequate empirical antibiotic therapy on the outcome of patients with systemic infection have led to inconsistent results. ⋯ Inadequate empirical antimicrobial therapy for community-onset BSI was associated with higher 30 day mortality rates. Study populations with different clinical severities may have different results, which may help to partly explain the heterogeneous findings in many similar studies.
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J. Antimicrob. Chemother. · Apr 2013
Multicenter Study Comparative StudyFluconazole versus an echinocandin for Candida glabrata fungaemia: a retrospective cohort study.
We studied whether fluconazole or echinocandin treatment of Candida glabrata fungaemia results in superior outcomes. ⋯ Severity of illness and choice of antifungal predict response in patients with C. glabrata fungaemia. Antifungal choice, however, does not influence mortality. In addition, new CLSI C. glabrata fluconazole susceptibility breakpoints are predictive of response when fluconazole is dosed appropriately.