The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Apr 2015
Review Meta AnalysisAssociation between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies.
Several observational studies have been published investigating the association between oral fluoroquinolone use and the development of retinal detachment; however, the findings are not concordant. This study is a meta-analysis of the existing literature and estimates the overall absolute risk of such an event. ⋯ The findings of this systematic review and meta-analysis do not support an association between oral fluoroquinolone use and the development of retinal detachment. Given the low absolute risk, such an event would be rare if there were an association. The current prescribing practice for fluoroquinolones should not be altered because of a previously suggested potential risk of retinal detachment.
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J. Antimicrob. Chemother. · Apr 2015
ReviewOutpatient parenteral antimicrobial therapy and antimicrobial stewardship: challenges and checklists.
Outpatient parenteral antimicrobial therapy (OPAT) has become, for many countries, an established form of healthcare delivery. At the same time, there have been calls to ensure the prudent use of the existing antimicrobial armamentarium. For OPAT, this presents a dilemma. ⋯ OPAT should report to the antimicrobial stewardship team. Ideally the OPAT team should be formally represented within the stewardship framework. A checklist has been proposed to aid OPAT services in ensuring they meet their stewardship agenda.
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J. Antimicrob. Chemother. · Apr 2015
Safety and clinical outcomes of carbapenem de-escalation as part of an antimicrobial stewardship programme in an ESBL-endemic setting.
To evaluate the safety and clinical outcomes of patients who received carbapenem de-escalation as guided by an antimicrobial stewardship programme (ASP) in a setting where ESBL-producing Enterobacteriaceae are endemic. ⋯ This study suggests that the ASP-guided de-escalation of carbapenems led to comparable clinical success, fewer adverse effects and a lower incidence of the development of resistance. This approach is safe and practicable, and should be a key component of an ASP.
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J. Antimicrob. Chemother. · Apr 2015
An international cross-sectional survey of antimicrobial stewardship programmes in hospitals.
To report the extent and components of global efforts in antimicrobial stewardship (AMS) in hospitals. ⋯ The worldwide development and implementation of AMS programmes varies considerably. Our results should inform and encourage the further evaluation of this with a view to promoting a worldwide stewardship framework. The prospective measurement of well-defined outcomes of the impact of these programmes remains a significant challenge.