The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Mar 2016
What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?
The objectives of this study were to determine the effects of obesity on unbound trough concentrations and on the achievement of pharmacokinetic (PK)/pharmacodynamic (PD) targets of piperacillin and meropenem in critically ill patients. ⋯ This large dataset has shown that the presence of obesity in critically ill patients may affect piperacillin, but not meropenem, unbound trough concentrations.