The Journal of antimicrobial chemotherapy
-
J. Antimicrob. Chemother. · Mar 2017
Clinical TrialPopulation pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass to optimize dosing regimens for children undergoing cardiac surgery.
The objective of this study was to characterize cefazolin serum pharmacokinetics in children before, during and after cardiopulmonary bypass (CPB), in order to derive an evidence-based dosing regimen. ⋯ We propose an optimized dosing regimen for cefazolin during cardiac surgery in paediatric patients to avoid treatment failure due to inadequate antibiotic prophylaxis.
-
J. Antimicrob. Chemother. · Mar 2017
Multicenter StudyEfficacy and tolerance of dolutegravir-based combined ART in perinatally HIV-1-infected adolescents: a French multicentre retrospective study.
To assess the safety and efficacy of a dolutegravir-based regimen in perinatally HIV-1-infected adolescents. ⋯ Dolutegravir was safe and virologically effective in these patients, for whom multiple interventions were required to improve compliance.