The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Oct 2020
Case ReportsPharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.
Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. ⋯ We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients. Further study of the pharmacokinetic profile of remdesivir, GS-441524 and the intracellular triphosphate form are required.