Cancer letters
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The Li-Fraumeni syndrome (LFS) is a dominant disease whose hallmark is an increased risk of breast cancers, brain tumours, sarcomas, leukaemia and adrenal carcinoma. Some, but not all LFS and Li-Fraumeni-like (LFL) families are caused by TP53 mutations. ⋯ No mutations were observed. This indicates that Bcl10 is unlikely to act as a susceptibility gene for LFS and LFL.