Neuroscience letters
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Neuroscience letters · Jun 1993
Distribution of NADPH-diaphorase in the cerebral blood vessels of rats: a histochemical study.
NADPH-diaphorase (neuronal nitric oxide synthase) activity in the cerebral blood vessels was investigated by light and electron microscopic histochemistry to elucidate the sites of nitric oxide production. Networks of adventitial nerves containing NADPH-diaphorase were distributed in all parts of the circle of Willis. ⋯ Endothelial cells were intensely stained in arteries and arterioles. These results support the hypothesis that vascular tone is regulated by nitric oxide, which is derived from endothelial cells and adventitial nerves.