Neuroscience letters
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Neuroscience letters · Aug 1993
The noradrenergic innervation density of the monkey paraventricular nucleus is not altered by early social deprivation.
A series of neuroanatomic analyses have been undertaken to identify potential neuropathological changes seen in monkeys exposed to early social deprivation, which leads to psychopathology, inappropriate responses to stress and appetitive disorders. The animals used in this study were either socially reared or maternal- and peer-deprived. ⋯ Quantitative analysis of dopamine-beta-hydroxylase-immunoreactive varicosity density within magnocellular and parvicellular regions revealed no significant differences between rearing conditions, suggesting that this chemically identified afferent input to the paraventricular nucleus was not affected by the early environmental insult of social deprivation. The apparent lack of vulnerability of the paraventricular nucleus to differential rearing conditions contrasts with the neuropathological changes observed in several discrete brain regions.
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Neuroscience letters · Aug 1993
Fos induction in brainstem neurons by intravenous hypertonic saline in the conscious rat.
Experiments were done in conscious rats to investigate the effect of intravenous infusion of hypertonic saline on the induction of the protein Fos, in brainstem neurons. Neurons containing Fos-like immunoreactivity were observed in the caudal nucleus of the solitary tract (NTS), the caudal and rostral ventrolateral medulla, and parabrachial nucleus after an infusion of solutions containing 1.4 M NaCl. Little or no expression of Fos was detected in brainstem neurons after intravenous infusions of either physiological (143 mM) or hypotonic (106 mM) NaCl solutions. These data provide evidence for the involvement of brainstem structures in osmoregulatory functions and suggest that brainstem neuronal circuits that function in cardiovascular regulation may also be shared by those involved in body fluid homeostasis.