Neuroscience letters
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Neuroscience letters · Aug 1996
Clinical TrialTopical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia.
The effect of acetylsalicylic acid (ASA) on capsaicin-evoked activation of cutaneous nociceptors was tested in a double blind study in 10 volunteers. Capsaicin (2% in ethanol) was applied topically for 30 min. ⋯ In contrast, capsaicin-induced heat hyperalgesia was unaffected by ASA. It is concluded that ASA counteracts the excitatory effects of capsaicin on nociceptors and mechanical hyperalgesia but not its sensitizing action to heat.