Neuroscience letters
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Neuroscience letters · Nov 2000
Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system.
Using immunocytochemistry with an antibody raised to a specific rat bradykinin B1 receptor sequence, we showed that the B1 receptor was expressed in the naive rat sensory nervous system. B1 immunoreactivity was seen in laminae 1 and 2 of the dorsal horn of the spinal cord, where primary afferents terminate, and on peripheral nerve terminals in the bladder. ⋯ B1 activation has an important role in the hyperalgesia associated with inflammation, but the site of action of B1 antagonists has generally been believed to be on peripheral, non-neuronal cells. The striking distribution of B1 receptors on sensory neurones suggests that a direct action of B1 activators on the nervous system may also contribute to hyperalgesia.
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Neuroscience letters · Nov 2000
Abnormal synaptic organization between granule cells and Purkinje cells in the new ataxic mutant mouse, pogo.
The pogo mouse is a new ataxic mutant derived from the Korean wild mouse. The pathological manifestations include difficulty in maintaining normal posture and the inability to walk straight. The ataxia becomes apparent at about 2 weeks of age. ⋯ Major difference between pogo/pogo homozygous and non-affected pogo/+ heterozygous was the synaptic organization of the molecular layer. Parallel fiber varicosities were larger than normal and a single fiber often established synaptic contacts with up to four dendritic spines of a Purkinje cell. This correlation between the presence of altered synaptic organization in the cerebellum and ataxia in pogo/pogo mutant mice warrants further investigation.