Neuroscience letters
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Neuroscience letters · Apr 2020
ReviewAutomated quantitative assessment of cerebral edema after ischemic stroke using CSF volumetrics.
Reduction in CSF volume from baseline to follow-up CT at or beyond 24 -hs can serve as a quantitative biomarker of cerebral edema after stroke. We have demonstrated that assessment of CSF displacement reflects edema metrics such as lesion volume, midline shift, and neurologic deterioration. ⋯ Finally, we have created a stroke repository that can archive and process images from thousands of stroke patients in order to measure CSF volumetrics. We plan on applying this metric as a quantitative endophenotype of cerebral edema to facilitate early prediction of clinical deterioration as well as large-scale genetic studies.