The Orthopedic clinics of North America
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Orthop. Clin. North Am. · Apr 2009
ReviewBisphosphonates and osteonecrosis: potential treatment or serious complication?
They are commonly used to treat osteoporosis and other diseases that involve osteoclast-mediated bone resorption, including Paget's disease and multiple myeloma. Their use in treating osteonecrosis of the femoral head has been studied and theoretically holds promise. There are complications associated with these medications, however, including the development of osteonecrosis in the jaw.