The Journal of dermatology
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Case Reports
Purpura fulminans secondary to Xanthomonas maltophilia sepsis in an adult with aplastic anemia.
Purpura fulminans is a rare disease characterized by purpura ecchymosis, hypotension, and fever associated with disseminated intravascular coagulation. It often begins as a benign infectious process and subsequently progresses to a severe, catastrophic outcome. ⋯ We present an unusual case of an adult with Xanthomonas maltophilia sepsis that subsequently developed into purpura fulminans with involvement of the four extremities. We discuss the importance of the protein C system in coagulation homeostasis and its relationship to purpura fulminans.
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Dermatitis caused by contact with tentacles of jellyfish was studied on 25 volunteers. Two tentacles cut from a living jellyfish, Carybdea rastonii, were applied on each of the forearms and skin reactions were observed. All volunteers complained of severe pain, which lasted from 10 min to 8 hrs. ⋯ These flare-up lesions lasted for one week leaving slight pigmentation. Histological findings from the flare-up lesions corresponded to those of allergic contact dermatitis. The lymphocyte response to the jellyfish venom in the subjects who had recurring lesions was greater than that in either the subjects with no recurring lesions or the control group, who was never exposed to jellyfish.
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A case of female with a large cystic tumor in her infrascapular region is reported. The tumor was 8 cm x 7 cm in size. ⋯ Because she had suffered from overlap syndromes of systemic lupus erythematosus, progressive systemic sclerosis, and suspected dermatomyositis, we diagnosed this a unique case of dystrophic calcinosis. There have been several reports of cases with connective tissue diseases showing subcutaneous calcification, but to our knowledge no such giant calcifying pseudocyst has ever been reported.
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A case of fixed drug eruption induced by minocycline on the glans penis of a 26-year-old man is reported. Later oral administration of minocycline reproduced the same type of eruption, but tetracycline, possessing the same starting structure as minocycline, did not induce the eruption. Laboratory findings were normal. This seems to be the first case of fixed drug eruption induced by minocycline to appear in the literature.