The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group.
Postmenopausal osteoporosis is a serious health problem, and additional treatments are needed. ⋯ Daily treatment with alendronate progressively increases the bone mass in the spine, hip, and total body and reduces the incidence of vertebral fractures, the progression of vertebral deformities, and height loss in postmenopausal women with osteoporosis.