The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Effects of estrogen replacement on the progression of coronary-artery atherosclerosis.
Heart disease is a major cause of illness and death in women. To understand better the role of estrogen in the treatment and prevention of heart disease, more information is needed about its effects on coronary atherosclerosis and the extent to which concomitant progestin therapy may modify these effects. ⋯ Neither estrogen alone nor estrogen plus medroxyprogesterone acetate affected the progression of coronary atherosclerosis in women with established disease. These results suggest that such women should not use estrogen replacement with an expectation of cardiovascular benefit.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A comparison of suture repair with mesh repair for incisional hernia.
Incisional hernia is an important complication of abdominal surgery. Procedures for the repair of these hernias with sutures and with mesh have been reported, but there is no consensus about which type of procedure is best. ⋯ Among patients with midline abdominal incisional hernias, mesh repair is superior to suture repair with regard to the recurrence of hernia, regardless of the size of the hernia.