The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Saline or albumin for fluid resuscitation in patients with traumatic brain injury.
In traumatic brain injury resuscitation with albumin is associated with a higher mortality than resuscitation with saline.
pearl -
Randomized Controlled Trial Multicenter Study
Prophylactic cranial irradiation in extensive small-cell lung cancer.
We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had had a response to chemotherapy. ⋯ Prophylactic cranial irradiation reduces the incidence of symptomatic brain metastases and prolongs disease-free and overall survival. (ClinicalTrials.gov number, NCT00016211 [ClinicalTrials.gov].).
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Randomized Controlled Trial Multicenter Study Comparative Study
Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia.
Effective ways to prevent arthropathy in severe hemophilia are unknown. ⋯ Prophylaxis with recombinant factor VIII can prevent joint damage and decrease the frequency of joint and other hemorrhages in young boys with severe hemophilia A. (ClinicalTrials.gov number, NCT00207597 [ClinicalTrials.gov].).