The New England journal of medicine
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Letter Case Reports
Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect.
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Editorial Comment
Another selective estrogen-receptor modulator for osteoporosis.
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Randomized Controlled Trial Multicenter Study
Dose of prophylactic platelet transfusions and prevention of hemorrhage.
We conducted a trial of prophylactic platelet transfusions to evaluate the effect of platelet dose on bleeding in patients with hypoproliferative thrombocytopenia. ⋯ Low doses of platelets administered as a prophylactic transfusion led to a decreased number of platelets transfused per patient but an increased number of transfusions given. At doses between 1.1x10(11) and 4.4x10(11) platelets per square meter, the number of platelets in the prophylactic transfusion had no effect on the incidence of bleeding. (ClinicalTrials.gov number, NCT00128713.)
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Randomized Controlled Trial
Newborn-care training and perinatal mortality in developing countries.
Of the 3.7 million neonatal deaths and 3.3 million stillbirths each year, 98% occur in developing countries. An evaluation of community-based interventions designed to reduce the number of these deaths is needed. ⋯ The rate of neonatal death in the 7 days after birth did not decrease after the introduction of Essential Newborn Care training of community-based birth attendants, although the rate of stillbirths was reduced. Subsequent training in the Neonatal Resuscitation Program did not significantly reduce the mortality rates. (ClinicalTrials.gov number, NCT00136708.)