The New England journal of medicine
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The U.S. diet is high in salt, with the majority coming from processed foods. Reducing dietary salt is a potentially important target for the improvement of public health. ⋯ Modest reductions in dietary salt could substantially reduce cardiovascular events and medical costs and should be a public health target.
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Randomized Controlled Trial Multicenter Study Comparative Study
Long-term results of hypofractionated radiation therapy for breast cancer.
The optimal fractionation schedule for whole-breast irradiation after breast-conserving surgery is unknown. ⋯ Ten years after treatment, accelerated, hypofractionated whole-breast irradiation was not inferior to standard radiation treatment in women who had undergone breast-conserving surgery for invasive breast cancer with clear surgical margins and negative axillary nodes. (ClinicalTrials.gov number, NCT00156052.)
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The effect of childhood risk factors for cardiovascular disease on adult mortality is poorly understood. ⋯ Obesity, glucose intolerance, and hypertension in childhood were strongly associated with increased rates of premature death from endogenous causes in this population. In contrast, childhood hypercholesterolemia was not a major predictor of premature death from endogenous causes.
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Randomized Controlled Trial Multicenter Study Comparative Study
Stent graft versus balloon angioplasty for failing dialysis-access grafts.
The leading cause of failure of a prosthetic arteriovenous hemodialysis-access graft is venous anastomotic stenosis. Balloon angioplasty, the first-line therapy, has a tendency to lead to subsequent recoil and restenosis; however, no other therapies have yet proved to be more effective. This study was designed to compare conventional balloon angioplasty with an expanded polytetrafluoroethylene endovascular stent graft for revision of venous anastomotic stenosis in failing hemodialysis grafts. ⋯ In this study, percutaneous revision of venous anastomotic stenosis in patients with a prosthetic hemodialysis graft was improved with the use of a stent graft, which appears to provide longer-term and superior patency and freedom from repeat interventions than standard balloon angioplasty. (ClinicalTrials.gov number, NCT00678249.)