The New England journal of medicine
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Randomized Controlled Trial Comparative Study
Bariatric surgery versus intensive medical therapy in obese patients with diabetes.
Observational studies have shown improvement in patients with type 2 diabetes mellitus after bariatric surgery. ⋯ In obese patients with uncontrolled type 2 diabetes, 12 months of medical therapy plus bariatric surgery achieved glycemic control in significantly more patients than medical therapy alone. Further study will be necessary to assess the durability of these results. (Funded by Ethicon Endo-Surgery and others; ClinicalTrials.gov number, NCT00432809.).
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Randomized Controlled Trial Comparative Study
Low-dose abdominal CT for evaluating suspected appendicitis.
Computed tomography (CT) has become the predominant test for diagnosing acute appendicitis in adults. In children and young adults, exposure to CT radiation is of particular concern. We evaluated the rate of negative (unnecessary) appendectomy after low-dose versus standard-dose abdominal CT in young adults with suspected appendicitis. ⋯ Low-dose CT was noninferior to standard-dose CT with respect to negative appendectomy rates in young adults with suspected appendicitis. (Funded by GE Healthcare Medical Diagnostics and others; ClinicalTrials.gov number, NCT00913380.).