The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Randomized trial of peanut consumption in infants at risk for peanut allergy.
The prevalence of peanut allergy among children in Western countries has doubled in the past 10 years, and peanut allergy is becoming apparent in Africa and Asia. We evaluated strategies of peanut consumption and avoidance to determine which strategy is most effective in preventing the development of peanut allergy in infants at high risk for the allergy. ⋯ The early introduction of peanuts significantly decreased the frequency of the development of peanut allergy among children at high risk for this allergy and modulated immune responses to peanuts. (Funded by the National Institute of Allergy and Infectious Diseases and others; ClinicalTrials.gov number, NCT00329784.).
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The author summarizes emerging standards for informed consent as the underpinning of ethical research in humans.
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Comment Letter
The concept of risk in comparative effectiveness research.
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Comment Letter
The concept of risk in comparative effectiveness research.