The New England journal of medicine
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Editorial Comment
Preventing HIV in women--still trying to find their VOICE.
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Randomized Controlled Trial Multicenter Study Comparative Study
Tenofovir-based preexposure prophylaxis for HIV infection among African women.
Reproductive-age women need effective interventions to prevent the acquisition of human immunodeficiency virus type 1 (HIV-1) infection. ⋯ None of the drug regimens we evaluated reduced the rates of HIV-1 acquisition in an intention-to-treat analysis. Adherence to study drugs was low. (Funded by the National Institutes of Health; VOICE ClinicalTrials.gov number, NCT00705679.).