International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Dec 2004
Comparative StudyProstate seed implantation using 3D-computer assisted intraoperative planning vs. a standard look-up nomogram: Improved target conformality with reduction in urethral and rectal wall dose.
To compare dosimetric outcomes between two real-time prostate seed implantation (PSI) techniques to evaluate the impact of three-dimensional (3D) intraoperative computer planning on target coverage, conformality, and preset urethral and rectal dose constraints. ⋯ The adoption of 3D computer intraoperative dose planning and optimization for prostate seed implantation resulted in dramatic reductions in urethral and rectal wall doses, while consistently producing excellent target coverage with reduced dose variability above 180 Gy and below 140 Gy, compared with the use of a standard look-up nomogram. Additionally, the reduction in total mCi and number of seeds needed to achieve improved conformality was substantial and may have implications for cost savings.
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Int. J. Radiat. Oncol. Biol. Phys. · Dec 2004
Magnetic resonance assessment of prostate localization variability in intensity-modulated radiotherapy for prostate cancer.
To measure prostate motion with magnetic resonance imaging (MRI) during a course of intensity-modulated radiotherapy. ⋯ All pretreatment positions were representative of the subsequent on-treatment positions. A clinical target volume (CTV) expansion of 5.3 mm in any direction was sufficient to ascertain a 95% coverage of the CTV within the planning target volume (PTV), provided that a rectal suppository is administered to avoid rectal overdistension and that the patient has a comfortably filled bladder (<300 mL).
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Int. J. Radiat. Oncol. Biol. Phys. · Dec 2004
Radiotherapy is a cost-effective palliative treatment for patients with bone metastasis from prostate cancer.
To evaluate the various treatments for patients with hormone-refractory prostate cancer with bone metastases using a Markov model. ⋯ Within the limits of the established model, single-fraction RT was the most cost-effective palliative treatment compared with pain medication, chemotherapy, and multifraction RT. The use of this model allowed comparison of different treatment regimens that could never be evaluated together in a randomized clinical trial.